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Clinical Trials

Active Studies (Currently Enrolling)

We are currently enrolling patients in the clinical trials or studies listed below. Patients need to meet the criteria for study enrollment before entry into these clinical trials. Please contact us if you would like to consider participating in one of these studies. If you have a general interest in research or clinical trials, contact GIHH@dchstx.org.

Atopic Dermatitis

A Study Assessing Rocatinlimab (AMG 451) Monotherapy in Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-Horizon) (ROCKET-Horizon)

Sponsor: Amgen

Principal Investigator: Emily Becker, MD

Primary Contact Person: Jennifer Cantu, RN

361-694-4455

Jennifer.Cantu@dchstx.org

COVID-19

A Study to Learn About Variant-Adapted COVID-19 RNA Vaccine Candidate(s) in Healthy Children

Sponsor: Pfizer

Principal Investigator: Jaime Fergie, MD

Primary Contact Person: Ruth Longoria

361-694-5979

Ruth.Longoria@dchstx.org

Migraine

A Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine (PIONEER-PEDS1)

Sponsor: Eli Lilly

Principal Investigator: Marcos Valdez, MD

Primary Contact Person: Ruth Longoria

361-694-5979

Ruth.Longoria@dchstx.org

PCOS

Nutrition for Optimal Reproductive and Adolescent Health (NORAH) for female ages 9-21 year old with irregular menses and is within 6 years of its start

Principal Investigator: Heidi Vanden Brink, PhD MS RDMS

Primary Contact Person: Rosalie Castaneda, FNP-C

361-694-4025

Rosalie.Castaneda@dchstx.org

RSV

A Study to Evaluate EDP 938 Regimens in Children With RSV (RSVPEDs)

Sponsor: Enanta Pharmaceuticals

Principal Investigator: Jon Roberts, MD

Primary Contact Person: Rosalie Castaneda, FNP-C

361-694-4025

Rosalie.Castaneda@dchstx.org

Active Studies (No Longer Enrolling)

A Long-term Extension Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis

Sponsor: Amgen

Principal Investigator: Emily Becker, MD

Chronic Kidney Disease in Children (CKiD) Study

Sponsor: NIH – CHOP

Principal Investigator: Amy Becker, MD

Clesrovimab (MK-1654) in Infants and Children at Increased Risk for Severe Respiratory Syncytial Virus (RSV) Disease (MK-1654-007)

Sponsor: Merck Sharp & Dohme LLC

Principal Investigator: Jamie Eduardo Fergie, MD

Study of Sparsentan in Patients With Primary Focal Segmental Glomerulosclerosis (FSGS) (DUPLEX)

Sponsor: Travere Therapeutics, INC

Principal Investigator: Amy Becker, MD

Completed Studies

A Phase 1/ 2/ 3 Study to Evaluate the Safety, Tolerability, and Immunogenicity of an RNA Vaccine Candidate Against COVID-19 in Healthy Children

Sponsor: Pfizer

Principal Investigator: Jamie Eduardo Fergie, MD

A Study to Investigate the Efficacy and Safety of Canagliflozin in Children and Adolescents (>=10 to <18 Years) With Type 2 Diabetes Mellitus

Sponsor: Janssen Research & Development, LLC

Principal Investigator: Ana Maria Paez, MD

A Study of Immune System Proteins in Participants With Mild to Moderate COVID-19 Illness (BLAZE-4)

Sponsor: Eli Lilly and Company

Principal Investigator: Estela Maria O’Daniell, MD

A Study to Evaluate the Safety of MEDI8897 for the Prevention of Medically Attended Respiratory Syncytial Virus (RSV) Lower Respiratory Track Infection (LRTI) in High-risk Children

Sponsor: AstraZeneca

Principal Investigator: Jamie Eduardo Fergie, MD

Efficacy and Safety Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis (SPROUT)

Sponsor: Amgen, Inc. / PPDI

Principal Investigator: Emily Becker, MD

Posaconazole (MK-5592) Intravenous and Oral in Children (<2 Years) With Invasive Fungal Infection (MK-5592-127)

Sponsor: Merck Sharp & Dohme Corp.

Principal Investigator: Farha Sherani, MD

Real-world Effectiveness of Elexacaftor/Tezacaftor/Ivacaftor on Burden of Illness in Cystic Fibrosis Patients

Sponsor: Vertex Pharmaceuticals Inc.

Principal Investigator: Jon Roberts, MD

A Phase 3 Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF)

Sponsor: Vertex Pharmaceuticals Inc.

Principal Investigator: Jon Roberts, MD

Viral Testing in the Setting of Neonatal Fever

Sponsor: Baylor College of Medicine

Principal Investigator: Jamie Eduardo Fergie, MD